Genetic Approaches

Proteomic Analysis of Integrin Associated Complexes

The data in this table were published in: JD Humphries, A Byron, MD Bass, SE Craig, JW Pinney, D Knight, MJ Humphries. (2009) "Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6." Science Signaling 2:ra51 PubMed

Integrin Associated Complexes

Notes:

¹Human International Protein Index (IPI) database identifier(s).

²Fold enrichments of proteins identified in FN or VCAM-1 affinity isolations versus the VCAM-1(D40A) control isolation were calculated from mean normalised spectral counts. Fold enrichments of proteins detected in FN or VCAM-1 affinity isolations but not in the VCAM-1(D40A) control isolation could not be determined (ND).

³Proteins enriched by at least 2.0-fold over the VCAM-1(D40A) control sample were regarded as specific. Proteins not enriched in a specific adhesion complex are indicated by a dash (-).

⁴Number of direct protein-protein interactions between selected protein and integrin beta1 based on analysis of the alpha5beta1-FN and alpha4beta1-VCAM-1 interaction networks in the study. Proteins that did not link to the major interconnected interaction networks derived from alpha5beta1-FN and alpha4beta1-VCAM-1 adhesion complexes were deemed not connected (NC). Proteins not present in the human interactome at the time of the study, and, therefore, that could not be mapped onto the interactome, are indicated by a cross (X). Proteins not enriched in a specific adhesion complex are indicated by a dash (-).