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Welcome to the February 2012 Cell Migration Update, your one-stop resource for news, highlights and research on cell migration.

CELL MIGRATION @ NATURE.COM

A comprehensive library of the latest research related to cell migration

Cell migration: H2O2 sensing: the missing 'Lynk'

Mhairi Skinner Nature Reviews Molecular Cell Biology

A novel GRK2/HDAC6 interaction modulates cell spreading and motility

Vanesa Lafarga, Ivette Aymerich, Olga Tapia, Federico Mayor, Petronila Penela The EMBO Journal

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Naoko Kaneko, Kazunobu Sawamoto, Keisuke Watanabe, Hirohide Takebayashi, Hiroshi Kiyonari, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya Nature Neuroscience

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

Janine M van Gils, Merran C Derby, Luciana R Fernandes, Bhama Ramkhelawon, Tathagat D Ray, Katey J Rayner, Sajesh Parathath, Emilie Distel, Jessica L Feig, Jacqueline I Alvarez-Leite, Alistair J Rayner, Thomas O McDonald, Kevin D O'Brien, Lynda M Stuart, Edward A Fisher, Adam Lacy-Hulbert, Kathryn J Moore Nature Immunology

ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas

E Colas, L Muinelo-Romay, L Alonso-Alconada, M Llaurado, M Monge, J Barbazan, M Gonzalez, M Schoumacher, N Pedrola, T Ertekin, L Devis, A Ruiz, J Castellvi, A Doll, A Gil-Moreno, M Vazquez-Levin, L Lapyckyj, R Lopez-Lopez, S Robine, E Friederich, M Castro, J Reventos, D Vignjevic, M Abal Oncogene

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FEATURED ARTICLES

Editor's reviews of the hottest new articles

Increase in tension forces movement in one direction

Increased tension at the plasma membrane generated by cell protrusion at the leading edge functions as a long-range inhibitor of Rac activation and further protrusion.

Katrin Legg Original research paper: Cell 148, 175–188 (2012)

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CONSORTIUM NEWS

The latest news from the CMC

The actin cytoskeleton in endocytosis: pushing the latest model

Probing phosphorylation-mediated protein partnerships

Consortium Data Additions & Site Updates

Upcoming Conferences & Workshops

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CELL MIGRATION KNOWLEDGEBASE

From Zamir & Geiger 2001; J. Cell Sc. 114:3583-90. Reproduced with permission from the Company of Biologists.

Visit the Cell Migration Knowledgebase for the latest cell migration protein database entries.

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CONSORTIUM ACTIVITIES

From Nalbant et al. 2004; Science 305:1615-19. Reprinted with permission from AAAS.

Find out more about the Consortium activities, and the latest Consortium Updates.

RESEARCH HIGHLIGHTS

Synopses of important recent articles

Ovarian cancer: Driving force

Actomyosin-mediated contractility in ovarian cancer cells induces mesothelial cells to de-adhere and move away, facilitating penetration of the mesothelial barrier during metastasis.

Sarah Seton-RogersNature Reviews Cancer 11, 538 - 539 (2011)

Innate immunity: Neutrophil U-turn fans the flames

The expression of junctional adhesion molecule C in endothelial cells is required to prevent reverse transendothelial migration of neutrophils.

Yvonne BordonNature Reviews Immunology 11, 498 (2011)

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